New Publication: The Utility of DiceCT Imaging for High-Throughput Comparative Neuroanatomical Studies

KargerBBE_GignacKley
DiceCT facilitates the rapid visualization of both external and internal brain anatomy in vertebrates – alongside the intact bones of the skull and the complete, undisturbed pathways of peripheral nerves, up to and including the target organs that they innervate. This approach allows for the digital extraction of vertebrate brains across 10,000-fold ranges in specimen size and at micron-scale resolutions.

” Like the current ‘gold standard’ of magnetic resonance imaging, diceCT does not require physical dissection and can differentiate between the lipid content of myelinated versus nonmyelinated tissues, thereby offering great potential for neuroanatomical studies. Within the brain diceCT distinguishes myelinated fiber tracts from unmyelinated cortices, nuclei, and ganglia and allows 3D visualization of their anatomical interrelationships at previously unrealized spatial scales. In our open access study,  we demonstrate the transformative potential of diceCT for developing high-resolution neuroanatomical datasets and describe best practices for imaging large numbers of specimens for broad evolutionary studies across vertebrates.”

– lead author, Paul Gignac (@)

Head over to Brain, Behavior and Evolution to read this open access pub and find more excellent neuroscience from the Karger workshop special edition, From Fossils to Function: Integrative and Taxonomically Inclusive Approaches to Vertebrate Evolutionary Neuroscience

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